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Nevertheless, bortezomib-induced peripheral neuropathy (BIPN), which is the most frequent and severe side effect of BTZ therapy, has become an increasing concern in the management of MM (Park et al., 2013

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FIGURE 9 The core of this toxicity mechanism lies in the depletion of the labile Fe 2+ pool (Figure 5B)—without altering total cellular iron (Figure 5A)—which triggers a compensatory iron-starvation response (IREB2↑, TfR1↑, Ferritin↓